IL-10, transforming growth factor beta (TGF-β), and Wnt ligands from hepatocellular carcinoma (HCC) cells upregulate Wnt2b expression and promote M2 polarization in TAMs by activating the Wnt2b/β-catenin/c-Myc signaling axis and glycolysis 12. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.