CRTC1 and breast cancer: In breast cancer, lysosome associated membrane protein type 2A (LAMP2a) on the lysosomal membrane of TAMs degrades peroxiredoxin 1 (PRDX1) and CREB-regulated transcription coactivator 1 (CRTC1) via chaperone-mediated autophagy (CMA), reducing ROS generation and activating M2 polarization and tumor-promoting activities 34.