CCL2 and renal cell carcinoma: For instance, renal cell carcinoma (RCC) can induce M2-type macrophages to secrete CCL2, inhibiting muscleblind-like protein 2 (MBNL2)/B-cell lymphoma 2 (Bcl-2)/beclin 1-mediated autophagy in RCC cells, leading to cell growth and EMT 61.