Hypoxia-induced necrotic fragments of cancer cells, like HCC cells, and HIF-1α secreted by hypoxic tumor cells recruit TLR4 to the macrophage cell membrane, activating the toll-like receptor (TLR) 4/TIR-domain-containing adaptor-inducing interferon-β (TRIF)/NF-κB pathway. Here, TLR4 is linked to neoplasm.