Recent research also highlights the role of fatty acid binding protein 4 in transferring saturated fatty acids to induce macrophage pyroptosis, mediating the NOD-like receptor thermal protein domain-associated protein 3 (NLRP3)/IL-1β axis, further regulating EMT, and enhancing pancreatic cancer cell metastasis in patients with obesity 16. This evidence concerns the gene IL1B and familial pancreatic carcinoma.