SERPINH1 and neoplasm: As a protein with the most stable ability to stratify the risk of recurrence in both tumors and NATs of three HCC cohorts (Figure 3D), SERPINH1 exhibits the following characteristics: Firstly, compared to the NATs, SERPINH1 was significantly upregulated in tumors, and its expression increased in a stepwise manner with increasing malignancy in three HCC tumor subtypes (Figure 4A).