To explore the signal cascade between miR-6794-3p and GRHL2 in pancreatic cancer cells, we transfected miR-Cont- or miR-6794-3p mimic-MIA-PaCa-2 cells and miR-Cont- or miR-6794-3p inhibitor-transfected HPAF-II cells with pCont or pGRHL2 and siCont or siGRHL2, respectively. The gene discussed is GRHL2; the disease is familial pancreatic carcinoma.