A link between the DDR and EMT has been established, because cisplatin exposure of ovarian cancer cells results in USP1 phosphorylation by ATM and ATR, the two core kinases of the DDR; such a phosphorylation is required for binding to Snail, a process activating stemness feature that can ultimately induce cell reprogramming to favor survival. The gene discussed is USP1; the disease is ovarian cancer.