Importantly, the increase in lipid peroxidation in CRC cells transfected with si-PRDX1 was largely rescued by treatment with the NRF2 agonist TBHQ, indicating that NRF2 plays a critical role in suppressing ferroptosis induced by PRDX1 knockdown (Fig. 4E, F). Here, NFE2L2 is linked to colorectal carcinoma.