The TREM2-dependent gene program is required to fully differentiate into LAMs and loss of Trem2 aggravates obesity in terms of adipocyte hypertrophy, body fat accumulation and weight gain [132], although some non-haematopoietic Trem2-dependent effects might contribute to this phenotype [135]. This evidence concerns the gene TREM2 and obesity due to melanocortin 4 receptor deficiency.