These spatial differences likely result in a different microenvironment and may account for the observed functional differences: while FOLR2+ TAMs are strategically positioned to interact with T cells and are accordingly involved in mounting a possible adaptive immune response against the tumour by priming CD8+ T cells [212], moTAMs are in direct contact with (apoptotic) tumour cells and experience a hypoxic environment. This evidence concerns the gene CD8A and neoplasm.