The activity of most ImmPort pathways (antigen processing and presentation, antimicrobials, B cell receptor signaling pathway, chemokines and their receptors, cytokines and their receptors, interleukins and their receptors, natural killer (NK) cell cytotoxicity, T cell receptor signaling pathway, and tumor necrosis factor (TNF) family members and their receptors) is positively correlated with Cytotoxicity TCSS in pan‐cancer context. The gene discussed is TNF; the disease is cancer.