CD8A and neoplasm: Tumor‐associated macrophages (TAMs) are the major cell population of TIM, which not only nourish tumor cells but also contribute to tumor immunosuppressive microenvironment (TISM), including exhausting cytotoxic CD8+ T cells and recruiting immunosuppressive cells, like myeloid‐derived suppressor cells (MDSCs), regulatory T cells (Tregs), and so on [10].