A significant imbalance (SMD >0.10) was observed for covariates including age, enrollment year, household income, education, marital status, hypertension, hyperlipidemia, obesity, sleep disorders, home care, chronic morbidity index, number of diabetic complications, and use of antihypertensives, lipid-lowering drugs, insulin, and SGLT2 inhibitors, which were balanced after IPW (SMD <0.10) (Table 2 and Supplementary Figure S1). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.