Other downstream effects of CEBPB signaling include cytokine production, which causes neuroinflammation, as well as upregulation of δ-secretase, a key mediator of AD onset and progression which acts by cleaving both tau and Aβ to trigger formation of plaques and neurofibrillary tangles (Wang et al., 2018). This evidence concerns the gene CEBPB and Alzheimer disease.