CXCL10 and Alzheimer disease: CXCL10 secreted by adjacent astrocytes can act on CXCR3 in various cells and play a pathological role in three ways: (1) CXCL10 acting on CXCR3 in central neurons to activate the ERK1/2 pathway and induce the generation of amyloid deposits [42], (2) CXCL10 acting on CXCR3 on the membrane of T cells to regulate the aggregation of T cells to AD lesions and induce neuronal toxicity [71], and (3) CXCL10 produced directly or indirectly by fibrillar Aβ (fAβ) can bind to CXCR3 receptors on the membrane of microglia and reduce the phagocytosis of fAβ by microglia [69].