The CXCR3 pathway in the CNS plays a role in diseases, including glioblastoma, traumatic optic neuropathy (TON), neuropathic pain, and CNS degenerative diseases such as Alzheimer's disease (AD), multiple sclerosis (MS), prion diseases (PrD), and bipolar disorder (BD). Here, CXCR3 is linked to Alzheimer disease.