PF4 and nervous system disorder: CXCL4 was previously not considered to be involved in neurological diseases, but Piotrowska et al. [31] found that CXCL4 in the spinal cord continued to increase within 14 days after CCI, CXCL4 in the DRG continued to be strongly expressed from 7 to 28 days, and CXCL9 also continued to be strongly expressed in the late stage of neuropathic pain.