The previous findings indicate that CXCR3 exerts two opposing effects in glioma: (1) it promotes the dedifferentiation, migration, and invasion of tumors and recruits NK cells without a cytolytic effect, which seriously affects the prognosis of glioma patients; (2) CXCL9/CXCL10 secreted by tumors can recruit CXCR3-expressing T cells and enhance tumor immune responses. Here, CXCR3 is linked to central nervous system cancer.