CXCR3 and bone metastasis: Guan et al. [40] found that the expression levels of CXCL10 and CXCR3 in the rat spinal cord were significantly increased in a rat pain model of bone metastasis in breast cancer and that blocking the CXCL10/CXCR3 pathway could inhibit the activation of microglia and the development of cancer pain.