Further experiments showed that CXCR3 was widely expressed in various neurons in the DRG and spinal cord, and CXCR3 was strongly positively correlated with the localization and expression of Akt and ERK1/2, suggesting that CXCR3 in the spinal cord mediates cancer pain after breast cancer bone metastasis via the Akt or ERK1/2 pathway. The gene discussed is MAPK3; the disease is breast cancer.