In the present study, despite the inclusion of only two cases of triple-positive breast cancer (TPBC)—characterized by the concurrent positivity of ER, PR, and HER2, and classified as the luminal B molecular subtype—these patients demonstrated exceptionally high CIN scores and exhibited significant chromosomal abnormalities (Figure 2C). Here, ESR1 is linked to cervical squamous intraepithelial neoplasia.