Given that SWA measured here are frontally predominant (Fz), we first assessed whether baseline pre-frontal or orbitofrontal PiB-PET SUVR was associated with (i) mean SO% and delta% or (ii) mean SO-slope and delta-slope, respectively, while adjusting for baseline age, APOE ɛ4, PSG-PiB interval and OSA severity (mild versus moderate/severe). Here, APOE is linked to obstructive sleep apnea syndrome.