CTNNB1 and adrenal cortex carcinoma: Multiple somatic mutations have been identified in human APAs (≈5%),14 ACCs (≈16%, including the S45P mutation in the ACC from which H295R cells were derived),32 and other cancers.33 Somatic CTNNB1 p.D32N and p.S37Y mutations have not been described in human APAs but have been described in other human tumors.