CACNA1C and Hypertension: Interestingly, the reverse has been reported for GNA11 p.Q209 mutations in adrenal tissue adjacent to human APAs, where cDNA was heterozygous but genomic DNA was homozygous.13 Selective expression of CACNA1C in cat tumors may explain the apparently greater effectiveness of the nonselective dihydropyridine calcium channel blocker amlodipine in the treatment of hypertension due to PA in cats, when compared with humans.46–49