Additionally, MSCs derived from pluripotent stem cells have shown many advantages in cell proliferation, antimicrobial activity, and immunomodulation.46-48 GMP-grade MSCs derived from pluripotent stem cells have been used in clinical trials for refractory graft-versus-host disease (GVHD).49,50 Previous studies have found that the efficiency of obtaining iPS cells is closely related to cell morphology, proliferation levels, and the expression of endogenous factors.51 Therefore, it is worth further investigating whether iPSCs derived from CD146+NES+ HUMSCs have any advantages in these aspects. Here, MCAM is linked to graft versus host disease.