In individuals of various age groups, including newborns, kids, and grownups diagnosed with KMT2A‐r‐ALL, as well as children with KMT2A‐r‐AML, there are notable increases in the levels of gene expression of SYK, FLT3, JAK2/JAK3, BTK, and several SRC family protein tyrosine kinases (PTK). Here, JAK2 is linked to acute myeloid leukemia.