In KMT2A‐r acute leukemia, chromosomal rearrangements disrupt the KMT2A gene, leading to fusion with partner genes, including AF9, ENL, AF4, AFF6, AF10, ELL, and KMT2A‐PTDS, which together are responsible for most KMT2A fusions [12, 13]. Here, KMT2A is linked to acute leukemia.