Specifically, prior studies have shown that deleting the gene encoding IL-18 binding protein (IL18BP), a negative regulator of IL-18, leads to elevated IL-18 production and a loss of mucus-producing goblet cells in DSS-induced colitis,22 while IL-22 can directly induce the expression of several goblet cell mucins.21 Given the connection between inflammatory cytokine signaling and goblet cell function, we further investigated the impact of S. Typhimurium infection on this IEC subtype. The gene discussed is IL22; the disease is colitis.