Considerable crosstalk has been reported for IL-18 and IL-22, with the two cytokines maintaining and augmenting each other’s production during intestinal homeostasis and infection.33,36,37 To clarify the potential interdependence of IL-18 and IL-22 signaling during S. Typhimurium infection, we used Il18- and Il22-deficient mice. This evidence concerns the gene IL18 and infection.