We did find other mutations in CNA-quiet HNSCC, but after false discovery rate correction none remained other than TP53, CASP8, and HRAS. Collectively, the major mutational discrepancies detected between the CNA-other and -quiet groups, provide evidence that CNA-quiet tumors form a molecular distinct subclass within HPV-negative HNSCC. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.