TGF‐β1 plays a pivotal role in gallbladder cancer progression through several mechanisms: it regulates IGFBP‐2, which facilitates malignant progression,39 enhances metastasis via m6A modification of FOXA1,40 and upregulates TUG1, thereby promoting cell proliferation and metastasis.41 This evidence concerns the gene FOXA1 and gallbladder cancer.