TGF‐β1 plays a pivotal role in gallbladder cancer progression through several mechanisms: it regulates IGFBP‐2, which facilitates malignant progression,39 enhances metastasis via m6A modification of FOXA1,40 and upregulates TUG1, thereby promoting cell proliferation and metastasis.41 The gene discussed is IGFBP2; the disease is gallbladder cancer.