APP and Alzheimer disease: These results also indicate that AD-related spontaneous behavioral alterations do not require APP overexpression and are likely linked to the pathologically elevated levels of amyloid in AppNL-G-F mice.16,19 We also tested the role of neuroinflammation in AD-related spontaneous behavioral alterations by blocking fibrinogen-microglia interactions in 5xFAD-Fggγ390–396A mice.