In microfold (M) cells, GP2 acts as a microbiome-sensing receptor of the intestinal follicle-associated epithelium (FAE) which is involved in transcytosing FimH-positive bacteria and subsequently triggering an immune response against them [7] while soluble GP2 interacts with the bacterial adhesin FimH, reducing infection rates of enterotoxigenic E. coli in cell line models [9]. The gene discussed is GP2; the disease is infection.