GP2 and sclerosing cholangitis: Given the predictive power of mucosal loss of tolerance to particularly the larger GP2 isoform with disease severity in primary sclerosing cholangitis (PSC) [13], an autoimmune liver disease with male preponderance and dysbiosis [19], and the link of the male gender with higher fecal GP2 levels in this study, this may indicate a putative predisposition for the development of autoimmune cholangitis in males with high fecal GP2.