In a co-culture model of patient-derived melanoma cells and autologous tumour-infiltrating lymphocytes (TILs), the study identified known and novel mechanisms of immune resistance, including defects in the interferon-gamma (IFN-γ)-JAK/STAT signalling pathway and the antigen presentation pathway, as well as the loss/down-regulation of CD58 [51]. The gene discussed is SOAT1; the disease is neoplasm.