In our extensive analysis of the roles of TACR3 across various cancer types, we expanded our examination beyond the primary model in the study by Xu et al., which included partial digestion tumors such as ApcMin/+ colon tumors, ipMFC mouse gastric tumors, ipHCT human colon tumors, PDX patient-derived gastric xenografts, and LLC mouse lung tumors. This evidence concerns the gene TACR3 and colonic neoplasm.