Nonetheless, it would be interesting to test the role of this enzyme in sporadic colorectal cancer (CRC), notably because CTH i) is stimulated by the WNT pathway in human CRC cells (Fan et al. 2014) and ii) is more highly expressed in human colonoids that harbor mutations in the genes implicated in CRC development, i.e., APC and TP53, TP53 and SMAD4, or TP53, SMAD4, and KRAS (Ascencao et al. 2022). The gene discussed is SMAD4; the disease is colorectal carcinoma.