Thus, H2S may cause mucus disruption by reducing its disulfide bonds (Ijssennagger et al. 2016), and the administration of the H2S-producing bacterium Desulfovibrio indonesiensis and Atopobium parvulum exacerbates the development of TNBS colitis (Figliuolo et al. 2017) and spontaneous colitis in Il10−/− mice (Mottawea et al. 2016), respectively. The gene discussed is IL10; the disease is colitis.