Mechanistically, we determined that mice lacking the gene Slc7a11, which encodes for the transporter of the anionic form of cysteine, cystine, namely solute carrier family 7 member 11 (SCL7A11, also termed xCT), are not protected from DSS colitis, suggesting that the RTP-dependent synthesis of cysteine is not involved in the pathophysiology of colitis. This evidence concerns the gene SLC7A11 and colitis.