However, Akahoshi et al. have shown that C57BL/6 mice lacking Cth or Mpst, which encodes for the H2S generating enzyme mercaptopyruvate sulfurtransferase (THTM), do not show significant alteration of trinitrobenzene sulfonic acid (TNBS)- and oxazolone-induced colitis (Akahoshi et al. 2023). The gene discussed is CTH; the disease is colitis.