In line of this, 24 h after a 6 Gy irradiation of MCF7 breast cancer cells, Efimova et al. demonstrated that pharmacological inhibition of GFAT or OGT or knock-down of OGT was correlated with increased number of persisting Ionizing Radiation Inducing Foci (IRIF) compared to control cells thus suggesting that O-GlcNAcylation inhibition delay DNA repair [35, 39]. This evidence concerns the gene OGT and breast cancer.