We therefore first aimed to study the expression of enzymes of the HBP pathway and O-GlcNAcylation processes (Fig. 1A) upon chemotherapy-induced senescence in various colon cancer cell lines with different p53 statuses: in two MSI/dMMR cell lines expressing the wild-type TP53 gene: HCT116 and LS174T (Fig. 1, Supplementary Figs. S3 and S4) and in two MSS/CIN cell lines mutated for this gene: HT29 and Caco2 (Supplementary Fig. S5). This evidence concerns the gene TP53 and malignant colon neoplasm.