High levels of homocysteine can result from a variety of reasons including a dietary deficiency of vitamins B6, B12, and folate, genetic variation of the enzymes essential for the metabolism of homocysteine such as MTHFR and cystathionine beta-synthase, enzymes, gastric atrophy, inflammatory bowel disease and methionine loading [9, 16]. Here, MTHFR is linked to inflammatory bowel disease.