For example, ADGRG1 and IGSF9, both upregulated in PLHIV with fibrosis, were positively correlated with T2DM, presence of carotid plaques, prior myocardial infarction, duration of HIV and ART, and prior exposure to D-drugs and INSTI (Fig. 3b). The gene discussed is IGSF9; the disease is type 2 diabetes mellitus.