For example, IGSF9 correlated in lean PLHIV with HIV- and cART duration, CD4 nadir, CD4:CD8 ratio pre-cART, CD8 at enrollment, current treatment with NNRTI, exposure to raltegravir, prior exposure to D-drugs, myocardial infarction, T2DM, and presence of carotid plaque, whereas associations with HIV-characteristics and ART were very limited in overweight/obese PLHIV. Here, CD8A is linked to myocardial infarction.