CD8A and steatosis: Altogether, our observations of similar proteomic signatures of steatosis among overweight individuals with or without HIV, with minor correlations with HIV-related factors and ART, in contrast with a unique proteomic signature in lean PLHIV with steatosis with marked correlations with HIV-related factors (i.e. immunological non-responders, CD4:CD8 ratio pre-ART) and exposure to ART (i.e. dideoxynucleosides and INSTI) suggest that mechanisms related to HIV and ART contribute to liver steatosis in lean PLHIV.