Although the BGT1 transporterwas found to be expressed at low levels under normal conditions, itsinhibitors were proposed to have some anticonvulsant potential incertain forms of epilepsy.3,7 The most potent andselective BGT1 inhibitor is the rigid GABA analog—bicyclo-GABA((1S,2S,5R)-5-aminobicyclo[3.1.0]hexane-2-carboxylic acid) with submicromolar/micromolaractivity (IC50 = 0.59 μM/1.5 μM).11,12 It has not been tested in vivo so far, and thus,its antiepileptic effect remains unknown. Here, SLC6A12 is linked to epilepsy.