Zhu et al [104,105] reported that the level of KCa3.1 was increased in the coronary artery vessels of patients with coronary artery disease and that the expression and activity of KCa3.1 in VSMCs and macrophages infiltrating atherosclerotic lesions were increased, which promoted the accumulation of VSMCs and macrophages in plaques and their proliferation and formation. Here, KCNN4 is linked to coronary artery disorder.