TRPC6 and pulmonary arterial hypertension: For example, Masson et al [47,48] reported that the protein expression of TRPC6 in the pulmonary artery smooth muscle (PAH-hPASMCs) of patients with pulmonary hypertension was increased, and the SOCE of PAH-hPASMCs was increased twofold, accompanied by increased calcineurin activity, compared with that of hPASMCs in the control group.