Studies of TRPV4 expression and activity in fibroblasts suggest that increased TRPV4 expression is associated with skin fibrosis in scleroderma [62] and that the activity of TRPV4 channels is increased in the lung fibroblasts of patients with idiopathic pulmonary fibrosis [63]. The gene discussed is TRPV4; the disease is idiopathic pulmonary fibrosis.