On the basis of our immunohistochemical findings, experimental PI led to the detection of elevated levels of the pro-inflammatory cytokines IL-6 and TNF-α, and the markers IBA-1 and GFAP associated to activated microglia and astrocytes in the rat hippocampus and cerebral cortex, signs compatible with neuroinflammation associated to neurodegenerative diseases. The gene discussed is TNF; the disease is neurodegenerative disease.