TGFBR1 and pachyonychia congenita: Exosomes carrying exogenously high ZNF667-AS1 expression derived PC cells or serum of mice reduced the number of CD4+ T cells through interacting with RBP U2AF1-mediated promotion of TGFBR1 mRNA, thereby enhancing DTX sensibility to PC cells and suppressing PC progression (Fig. 8).