SIRT7 and precursor B-cell acute lymphoblastic leukemia: Stratification of pediatric individuals with B-ALL from the COG9906 study35,36 according to their SIRT7 mRNA expression indicated that those with higher than median SIRT7 mRNA levels had a better prognosis than those expressing lower than median SIRT7 mRNA (Fig. 6h), indicating that SIRT7 could be an independent prognostic factor in human B-ALL.