Interestingly, we found that LXN was almost exclusively expressed in endothelial cells (labeled by the marker CD31) in normal aorta, however, abundant of LXN invaded into the intimal layer at the plaque site in atherosclerosis mice (Supplemental Fig. S2A) and were significantly correlated with areas of aortic plaques in ApoE-/- mice (Supplemental Fig. S2C). This evidence concerns the gene APOE and atherosclerosis.