Note, under hypoxic conditions and through upregulation of the transcription factor PPARγ, miRNA-27b plays an essential role in lipid metabolism [41, 42] while silencing of miRNA-125b-5p promotes liver fibrosis in MASLD via integrin α8-mediated activation of the RhoA signaling pathway [43]. Here, PPARG is linked to metabolic dysfunction-associated steatotic liver disease.