In order to prove whether UBR7 deletion promoting the progression and drug resistance of pancreatic cancer was related to the regulation the expression of PRMT5, we overexpressed UBR7 and simultaneously overexpressed UBR7 and PRMT5 in PANC-1-GEM cells, and then transplanted the cells subcutaneously into nude mice (Fig. 7A). Here, UBR7 is linked to familial pancreatic carcinoma.