MYBPC3 and left ventricular hypertrophy: As such, the same MYBPC3 variant identified in a patient with a robust HCM phenotype is a confirmation of a genetic disease (both in population and clinical settings), whereas its detection in a patient with normal cardiac magnetic resonance imaging or mild left ventricular hypertrophy in the absence of other causes only raises the modest possibility that the left ventricular hypertrophy may have a genetic basis (ie, potentially caused by the MYBPC3 variant).