Next, they constructed diffuse large B cell lymphoma cell line models with PAX5-TSS2 deletion and point mutations and found that both PAX5-TSS2 deletion and point mutations could enhance the interaction between PAX5 enhancer region and ZCCHC7 promoter, leading to an increase in ZCCHC7 mRNA expression without substantial decrease in PAX5 expression. The gene discussed is ZCCHC7; the disease is diffuse large B-cell lymphoma.