Along these lines, ZEB2 is necessary for proper development of the anterior neural crest, and mutations in ZEB2 cause Mowat-Wilson syndrome, characterized by defects in the enteric nervous system (which is derived from the neural crest), craniofacial abnormalities, and intellectual disability.111 Given that the neural crest arises from the same original neuroepithelial primordium as the brain (Figure 3), this overlap may not be a coincidence. The gene discussed is ZEB2; the disease is Mowat-Wilson syndrome.