Connective tissue growth factor (CTGF), is a downstream target of TGF-β2 and is proposed to be a mediator of increased outflow resistance in POAG, with overexpression in the mouse eye leading to increases in IOP and optic nerve damage, correlated with induction of TM fibronectin and α-SMA (Junglas et al., 2012, Junglas et al., 2009). This evidence concerns the gene CCN2 and open-angle glaucoma.