OPA1 and Leber hereditary optic neuropathy: From the literature, among the cases of optic atrophy caused by OPA1, 84.31% (591/701) presented as non-syndromic optic atrophy (involving visual symptoms only), a rate that surpasses that of ACO2 (71.08%) but falls below DNAJC30 (which exhibits complete prevalence, 100%).