The median onset age of visual impairment in patients with OPA1 variants was 6.00 (1.75, 9.00) years in our in-house cohort, which was significantly earlier than that in the overall literature on OPA1-related age of disease onset but was not significantly different from that in large, published cohorts (Supplementary Fig. 15). The gene discussed is OPA1; the disease is Visual impairment.