RBP-associated disorders often include symptoms of behavioral abnormalities and cognitive impairments, including Fragile X Messenger Ribonucleoprotein (FMR1) in Fragile X syndrome involving cognitive impairment, PUMILIO1 (PUM1) associated developmental disability, ataxia, and seizures (PADDAS), Quaking (QKI) in schizophrenia, and both Heterogeneous Ribonucleoprotein K (HNRNPK) in Au-Kline syndrome and SON in Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome both involving intellectual disability [9–13]. The gene discussed is PUM1; the disease is Cognitive impairment.