Specifically, components of the human leukocyte antigens (HLA) class II encoded HLA-DRB1*03-DQA1*0501-DQB1*0201 and DRB1*04-DQA1*0301-DQB1*0302 haplotypes have been associated with various autoimmune diseases, including AAI [10,11]. The gene discussed is HLA-DRB1; the disease is autoimmune disease.