In the second study, the results of an examination of a patient with an atypical course of APS-2 manifesting in childhood and her parents suggest that the PTPN22, PJA2, CASR, and DDX60L genes, which are involved in the functioning of the endocrine and immune systems, may serve as genetic predictors of APS, particularly exhibiting a dominant-negative effect. This evidence concerns the gene PJA2 and autoimmune polyendocrinopathy.