Endo et al. reported that the genomic landscape of esophageal intraepithelial squamous cell neoplasia with epidermalization showed alterations commonly found in ESCC, such as TP53 missense mutation, copy number gain of PIK3CA, and CN loss of CDKN2A [18]. The gene discussed is CDKN2A; the disease is esophageal squamous cell carcinoma.