MYB and central nervous system cancer: In summary, our report of 14 cases in a defined methylation family, “Diffuse glioma, MYB- or MYBL1-altered” reveals several key issues: First, we note 2 cases of angiocentric glioma, which did not match to the specific angiocentric glioma subclass on methylation (Fig. 1a, b), highlighting the need to critically assess methylation profiling results within the context of the case in MYB/MYBL1-altered gliomas.