With respect to specific methylation class, the DKFZ Heidelberg classifier divides this family into 4 classes, labeled Angiocentric glioma, MYB/MYBL1-altered (AG_MYB), and Diffuse astrocytoma, MYB- or MYBL1-altered, subtypes B, C, and D. In our cohort, 4 cases matched to the Angiocentric glioma, MYB/MYBL1-altered class, and all 4 were deemed to represent angiocentric gliomas in the final integrated diagnosis (Table 1). The gene discussed is MYBL1; the disease is central nervous system cancer.