By comparison, 2 cases of diffuse astrocytoma, MYB- or MYBL1-altered (Cases 4 and 11), in which perivascular accumulation of tumor cells was not appreciated and which matched to the methylation classes, LGG_MYB_C and LGG_MYB_D, respectively, are also shown in Fig. 1c and d. The gene discussed is MYBL1; the disease is diffuse astrocytoma.