For instance, lEVs from adipocyte-specific PTP1B knockout mice [27] did not rescue palmitic-acid-evoked insulin resistance in 3T3L1 adipocytes (S. Ali, M. Delibégovic, M. Carmen Martínez, unpublished results), suggesting that adipose tissue-derived EVs were not involved in the effects observed in the present study. The gene discussed is PTPN1; the disease is Insulin resistance.