The TGF‐β signaling is an important regulator of metastasis pathways in many types of cancer, including melanomas, gliomas, and breast cancer.[31] The TGF‐β signaling pathway is initiated by the binding of TGF‐β to TGFBR2, which recruits and phosphorylates TGFBR1. The gene discussed is TGFB1; the disease is central nervous system cancer.