Several studies have revealed that HSCs are one of the important fibrogenic cell types in liver fibrosis, and may facilitate liver metastasis by remodeling liver premetastatic niche.[35] Given our previous findings that VGF regulates the TGF‐β signaling pathway, which is closely associated with fibrosis,[36] we next investigate whether VGF promotes colonization in the liver of UM cells through the activation of HSCs. The gene discussed is TGFB1; the disease is Hepatic fibrosis.