PLPP3 and cancer: In alignment with the ER's central role in lipid metabolism, a significant association between LPP3 expression and the enrichment score of KEGG_Glycerophospholipid_Metabolism in cancer cells was observed in two published RCC single‐cell datasets (Figure 5D).[38, 39] Given the high affinity of LPP3 for PA among all phospholipid substrates,[33] we questioned whether LPP3 could regulate the PA level in RCC cells.