Multiple studies have reported that mitochondrial PA can hinder its fission and result in mitochondrial elongation.[26, 45, 46] Intriguingly, both fluorescence microscopy and electron microscopy unveiled that LPP3 knockdown led to significantly longer mitochondria in RCC cells (Figure6A,B; Figure S5A, Supporting Information), without affecting the expression of recognized mitochondrial morphology regulators, such as dynamin‐related protein‐1 (DRP‐1), mitochondrial fission 1 protein (FIS1), mitofusin‐1 (MFN1), mitofusin‐2 (MFN2) and optic atrophy 1 (OPA1) (Figure S5B, Supporting Information). This evidence concerns the gene OPA1 and renal cell carcinoma.