Although RNA modifications have gained attention in RCC, including the downregulation of methyltransferase 14 (METTL14), which leads to cancer metastasis via glycolytic reprogramming,[20] and the significant role of FTO in the progression of VHL deficient RCC,[21] the function of m6Am in RCC remains unclear, despite its prevalence in 30% of the starting nucleotide in mRNA. The gene discussed is FTO; the disease is renal cell carcinoma.