However, abnormal aggregation of NK cells in the bone marrow could impair the hematopoietic function of the organism, and NK cells have a direct regulatory effect on the carcinogenesis of hematopoietic stem cells through the secretion of a series of pro-inflammatory factors, such as TNF-α and IFN-γ, which in turn will also contribute to the progression of Pre-T-ALL [34]. This evidence concerns the gene TNF and acute lymphoblastic leukemia.