ANGPT1/TEK is known to be a key signaling pathway in the developing and adult SC with GWAS linking it to ocular hypertension and glaucoma (Gharahkhani et al., 2021; Thomson et al., 2017; Souma et al., 2016; Kim et al., 2017; Figure 7A). This evidence concerns the gene ANGPT1 and ocular hypertension.