Among them, point mutations leading to the ε4 allele of apolipoprotein E (APOE) are known to be the most potent genetic risk factor for the common sporadic and late-onset forms of AD, as well as influencing rarer familial and early-onset forms of the disease (Saunders et al., 1993; Belloy et al., 2019; Sims et al., 2020; Serrano-Pozo et al., 2021). This evidence concerns the gene APOE and Alzheimer disease.