MAPT and Neurofibrillary tangles: It is hypothesized that soluble amyloid-β oligomers cause hyperphosphorylation of tau and the accumulation of neurofibrillary tangle (Zheng et al., 2002); however, the local relationship between amyloid and tau was restricted in several brain regions (Iaccarino et al., 2018), suggesting additional causes for tau accumulation.